The average heart rate decrease ranged from 24 beats per minute in sustained treatment, reflecting an overall cardiovascular benefit
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& Finck, B
The samples were fixed with 1% osmium tetroxide for 2 h, followed by gradient dehydration with acetone at 50, 75, 90, and 100% (repeated three times) for 15 min
1 The discovery of non-peptidic drugs has been hampered for many years, primarily owing to the difficulty of mimicking the peptidereceptor interactions with small molecule non-peptidic agonists
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